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Six human cancer cell lines exhibiting a large range of sensitivity to 5-fluorouracil (5-FU) were evaluated for thymidylate synthase (TS) and p53 gene expression, TS and dihydropyrimidine dehydrogenase (DPD) activity, as well as cell cycle parameters, S-phase fraction (SPF), bromodeoxyuridine labelling index (LI) and S-phase duration (SPD).
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Differences in test design as well as can account for some of this large range of species sensitivity.
As the state and parameter values may span a large range of magnitudes, normalized sensitivity values are often used to compare among states and parameters and to generate parameter ranking, which is given by: (8) In most systems biology applications of PSA, parameter rankings are generated from the sensitivity coefficients, either directly or using some consolidated sensitivity metrics.
Taking glucose oxidase (GOD) as the model, the proposed amperometric enzyme biosensor based on the Pt/CNx-CNTs shows excellent analytical characteristics to glucose detection, such as excellent sustainability in large range of pH values, high sensitivity (66.51 μA (mmol dm−3)−1 cm−2), wide linear range (0.01-6.1 mmol dm−3) and low detection limit (0.4 μmol dm−3).
Furthermore, a partially denaturing HPLC (pDHPLC) assay was developed to detect a large range of sequence variants with high sensitivity and low detection limits for minority alleles which could be a useful approach for routine detection of EGFR variants [ 58].
The suggested sensor has high sensitivity for a large range of working machines rotating parts angular speed measurement.
The ultrahigh imaging speed and high sensitivity for a large range of flow velocities make ultrahigh speed swept source/Fourier domain OCT an excellent technique for measuring total blood flow in papillary vessels.
Again, the assay was linear over a relatively large range of concentrations, indicating that the method displayed good sensitivity.
Testing results demonstrated that the sensor changes resistance within large range of relative humidity (RH) values (40 100% RH) with very high sensitivity.
Insects can detect a large range of odors with a numerically simple olfactory system that delivers high sensitivity and accurate discrimination.
This structure was able to locally measure a large range of tensile or compressive residual stresses in a thin film with sufficient sensitivities.
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