Accumulating evidence suggests that adipose tissue, as an endocrine organ producing and secreting a large range of factors, may interfere with cancer development.
Underlying pathways may involve a large range of factors, including patient factors (e.g., health behaviors, material conditions, or psychosocial factors) as well as characteristics of the providers, the community, and the health care system (6).
A large range of signalling factors including steroid hormones, peptide hormones, growth factors and other cytokines can induce activation of Creb1, usually via stimulation of pathways which increase intracellular levels of cAMP.
We finally showed our framework to be applicable to other prediction tasks, by demonstrating that our behavioral indicators (1) capture a large range of behavioral factors and (2) can be used to predict other demographic variables, such as age with regression (R^{2}=0.47) and income with 35% improvement in the multi-classification accuracy over random guessing.
We do agree with Wood who stated that "performing outcomes based research in education is difficult because of the large range of confounding factors" [ 18].
It suggests that the high diversity in GSTs is beneficial, possibly serving as a population wide protection against a large range of toxic factors in the environment.
In addition, motif analyses on accessible chromatin regions by FAIRE-seq identified motifs for a large range of other transcription factors previously linked to prostate cancer development and progression, including CTCF, SP1, FOS, and ETS domain family of transcription factors (Shemshedini et al, 1991; Lu et al, 2000; Taslim et al, 2012; Chen et al, 2013).
The same applies for the three CALUX assays, which represent a large range of possible risk-factor scenarios.
Instead, it was common to suppose that diseases reflected an imbalance of the four humors (blood, phlegm, and yellow and black bile), an imbalance ascribed to a large range of behaviors and environmental factors.
We finally show that our indicators capture a large range of behavioral traits using factor analysis and that the framework can be used to predict other indicators of vulnerability such as age or socio-economic status.
The data presented here shows a large range of vascular endothelial growth factor (VEGF) secretion (0.637 ng/106 cells/day to 3.25 ng/106 cells/day), cell migration (∼15 min < persistence time < 120 min, 0.11 μm/min < speed < 0.23 μm/min), and cell morphology (0.039 < form factor (FF) < 0.107).
