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PDZ domains were, for instance, found to have highly diverging membrane-binding behavior despite high sequence similarity (Chen et al., 2012) and PH domains span a large range of binding affinities though being structurally very similar (Lemmon and Ferguson, 2000; Singh and Murray, 2003).
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Despite this large range of metal dependencies, several metal-binding sites have been discovered in the most conserved domains of the group II introns, including D5 and D6.
It is a constitutively active cell surface receptor capable of binding and internalizing a large range of structurally and functionally different types of protein ligand, and has been shown to be essential for life [ 1].
The cyclic nucleotide-bound GAF domains from PDE2, −5, −6, and −10 all adopt a conserved fold but show subtle differences within the binding pocket architecture that account for a large range of nucleotide affinities and selectivity.
These materials typically exhibit an extremely complex array of chemical structures and interactions across a large range of size- and timescales, resulting in molecular signatures that reflect the fundamentals of chemical binding rather than those of their precursors.
The substrate-binding surface reveals an open topography, consistent with the ability to accept a large range of glycoprotein substrates and the ability to transglycosylate other acceptors.
There is a large range of possible mechanosensitive processes being involved at focal adhesions, including stress-sensitive ion channels, force-induced opening of cryptic binding sites and large-scale reorganization of the adhesions.
We showed that for a large range of physiologically relevant parameters, there are no significant differences between the continuous model and the RW model with respect to these binding events.
Notable societies: Large range of sports clubs.
A large range of materials was identified.
Spiders occur in a large range of sizes.
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