Large, protocol-driven individual patient data analyses are needed to accurately define this relationship further.
Although this may be more easily overcome in large protocol-driven institutions, GDM screening is often performed by private obstetricians, general practitioners, and community midwives.
Large protocol-driven, prospective studies are the ideal, with appropriate statistical analysis and clear, unbiased reporting of the methods used and the results obtained.
Our aim is to discuss how high-quality evidence can evolve over time from initial exploratory studies, to large protocol-driven primary studies, to meta-analysis and even beyond, to large prospectively planned pooled analyses, and to the initiation of tissue banks.
We discuss how better-quality prognostic marker evidence can evolve over time from initial exploratory studies, to large protocol-driven primary studies, and then to meta-analysis or even beyond, to large prospectively planned pooled analyses and to the initiation of tumour banks.
The present study was part of a larger protocol investigating SWI following CABG in a total of 374 patients.
This study was part of a larger protocol, which was approved by the Western Institutional Review Board.
10 13 The study protocol applied was part of a larger protocol for the survey of PwMS in Stockholm used at home visits with structured face-to-face interviews and tests.
Data for functional connectivity analysis were acquired as part of a larger protocol (Hedden et al., 2012a, 2014) on a Siemens TrioTim 3.0 Tesla scanner (Siemens, Erlangen, Germany) paired with a 12-channel phased-array head coil.
Furthermore, neurodevelopmental evaluations are often part of a larger protocol that includes collection of sociodemographic information from parents, a general medical evaluation of the child, and collection of biologic specimens such as blood, hair, and urine.
