Involvement of a relatively large proportion of recurrence pathways in tumorigenesis signifies that the biological processes associated with hepatocarcinogenesis also determine the prognostic process.
Indeed, IPA analysis identified that 163 canonical pathways were significantly associated with those genes (data not shown) with a large proportion of immune-related pathways in the first top 30 (Figure 2).
Consequently, a large proportion of predicted metabolic pathways are bacteria-specific that need to be deleted from the automated reconstruction of eukaryotes unless there is overwhelming evidence to the contrary.
A large proportion of indirect CM pathways, except for those mediated by segmental interneurons, remained intact in the present preparation (Sasaki et al., 2004; Isa et al., 2006; Nishimura et al., 2007).
The recovered proteins were unevenly distributed between various pathways, with a large proportion of components of the chromatin assembly pathway being present in both PfCK2β1 and PfCK2β2 precipitates, implicating PfCK2 in chromatin dynamics.
In contrast, the use of a complex but sensitive assay capable of identifying perturbations in thousands of potential targets simultaneously affords the possibility of uncovering a large proportion of all unknown modulators of biological pathways contained in these libraries.
Connector hubs constitute a large proportion of the long-range intra-hemispheric pathways within the cortical system, underscoring their potential importance for minimizing the number of processing steps [15].
We also observed transcript-level induction of a large proportion of genes in the trehalose biosynthetic pathway including 7 of the 8 trehalose phosphatases detectable on our array, as well as some (but not all) dehydrins (Table 2).
It has been suggested that women who metabolize a large proportion of their estrogen down the C-4 pathway, in contrast to the C-2 pathway, have elevated breast cancer rates, while the daughter estrogen metabolized down the C-16 route may be associated with a direct genotoxic effect and carcinogenicity [ 24].
When using degree (in and out) as the weight, the ER model outputs a larger proportion of significant pathways than does the BA model.
