Sentence examples for large potency from inspiring English sources

In a real GPCR, both potency and efficacy effects of ΔΔΨ may function in combination, although the large potency effect is likely to overshadow the small efficacy effect.

Figure 1 illustrates small chemical changes in compound pairs leading to large potency differences that are captured by MMP-cliffs.

In the practice of medicinal chemistry, structurally similar compounds with large potency differences are often encountered, mostly during the chemical optimization of individual compound series.

Accordingly, activity cliffs usually have high SAR information content (because small chemical changes in similar or analogous compounds lead to large potency effects).

This means that cliff partners are only involved in a single activity cliff and have no structural neighbors with large potency differences.

For example, Figure 4 shows two SARMs originating from a large data set that are highly ranked on the basis of SAR discontinuity (as indicated by the presence of multiple analogs with large potency differences).

These results indicate that bones which experience the largest strain relative to habitual loading might have the largest potency to show a response to mechanical loading (Warner et al. 2006).

This could suggest larger potency of the outdoor UFPs, compared with indoor UFPs, possibly by a factor of 3 considering the cubic root transformations.

Given that epibatidine shows large functional potency differences at α4 β2 vs. α4 α4 interfaces, biphasic binding properties would be expected at (α4 3 β2)2 receptors.

Using public bioactivity data, we have used MMPs as a consistent reference framework to identify sets of chemical replacements that either have the propensity to induce large-magnitude potency changes or tend to retain compound potency across diverse targets [3, 4].

It seems that the activity of ER agonism of a PCB is linked to its structure, as larger estrogenic potencies have been reported for low chlorinated compounds [ 49].