Supplement of Gal alone to the culture media allows the cells to add Gal to the GlcNAc terminals on O- and N-linked glycans and results in inhibiting Large-pathway to target GlcNAc terminals to generate the functional glycans.
As such, to obtain a significant p-value, larger pathways need to accumulate a larger number of gene amplifications or deletions.
We used the k-clique (k = 3) method to divide large pathways into multiple subpathways.
For Type 1, we found a large number of pathways to be activated, which are related to inflammation, angiogenesis, extracellular matrix, proliferation, and differentiation.
The inherent plasticity of the metabolic network may require pre-calculating a large number of pathways to guarantee that any biological scenario is properly represented.
The non-synonymous SNPs, frame-shift Indels and genes with SVs resulted from these polymorphisms caused a large number of pathways to be changed in B. juncea by KEGG analysis, for example, glucosinolate biosynthesis pathway.
If a bow-tie structure holds, one would expect nodes connecting to large number of pathways to have high Betweenness (B T ) and to therefore represent points of signal integration.
This is one of the largest studies of pathways to care for a first episode psychosis cohort, and made use of structured research instruments rather than clinical service definitions of first episode psychosis.
Large pathways or pathways with genes that reside in large LD blocks are likely to inflate the pathway statistic, although we accounted partially for this potential bias via the permutations procedure.
For example, large genes containing many SNPs are more likely to contain significant SNPs by chance alone and so are large pathways containing large genes.
