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In a large panel study of people with diabetes (O'Neill et al. 2005), several different measures of PM exposure were significantly associated with reductions in vascular reactivity.
Another large panel study, the Pollution Effects on Asthmatic Children in Europe (PEACE), was designed to examine the relationship between short-term changes in air pollution and lung function, respiratory symptoms and medication use [ 31].
The data came from a large panel study in Seattle, Washington, that collected indoor, outdoor, and personal exposure data on 107 subjects over a 2-year period (Liu et al. 2003).
As part of a large panel study in Seattle, Washington, we measured levels of exhaled nitric oxide (eNO) in children's homes and fixed-site particulate matter with aerodynamic diameters of 2.5 micro m or less (PM 2.5)) outside and inside the homes as well as personal PM 2.5) during winter and spring sessions of 2000-2001.
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Dr.Greif: All the data from large panel studies show that people with social networks do better.
Large panel studies to better understand and quantify the relationships between exacerbations, allergic sensitisation, directly measured pollen counts and other factors are required.
Our study results are consistent with those of a larger panel study in Seattle (Mar et al. 2005), but that study did see minor decreases in pulse rate in healthy subjects.
Children in the Seattle panel study spent an average of 66% of their time indoors at home and 21% indoors away from home (primarily at school), whereas the adults in the larger panel study in Seattle spent an average of 83 88% of their time indoors at home (Liu et al. 2003).
As the mechanism of PM effect on cardiovascular function remains unknown, we encourage performance of systemic measures of inflammation, thrombosis and oxidative stress in larger panel studies of susceptible populations and in controlled exposure studies to ambient PM in elderly individuals with and without cardiac and respiratory disease.
On the other hand, A large-scale panel study in European countries examined daily concentrations of PM10 and PEF in children with chronic respiratory symptoms in winter, and showed changes in morning and evening PEF for 10-μg/m3 increases in PM10 of 0.01 l/minute (N.S).
The "down-side" of our approach is that these studies were time consuming and laborious, and the donor-to-donor variability in human populations, and the relatively large panel of viruses studied, would have necessitated a high number of studies to reach statistical significance for the more nuanced differences between viruses, and forced us to interpret trends in differences.
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