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As commented previously, this was an unprecedented outbreak for an RNA virus capable of establishing a chronic, asymptomatic infection, which certainly contributed to its long duration and large number of infected patients.
These diseases have received special attention of public health officials due to the large number of infected people in tropical and subtropical countries and the possible sequels that those diseases can cause.
Transgenic releases into age-structured populations, which is an expectation for wild mosquitoes, will be difficult and depending on the circumstances may not be economically or logistically feasible due to the large number of infected mosquitoes that must be released.
Simply put, when a large number of infected individuals are present, uninfected individuals are more likely to take preventive action through vaccination, as the benefits of reduced infection risk rise even though the harms of side effects remain the same.
All cells (C_{pq}) become highly infected and the number (I^{C_{pq}}) becomes less and less important at further instants, noting that at (i=900), a large number of infected individuals has decreased because many (I^{C_{pq}}) have died or moved to the removed compartment.
At 4 dpi, hypomotility and absence of milk in the stomach were frequent clinical signs, and immunostaining for virus proteins revealed a large number of infected cells.
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Similarly, fluorescence microscopy analysis indicated relatively large numbers of infected (GFP-positive) cells among the PBMCs infected with virus produced from vector-transduced T cells (Fig. 7B, c and d).
In Iquitos, DHF was first reported during a DENV-3 epidemic in 2004 (M. Sihuincha and C. Rocha, pers. comm).. DHF had not been observed after the introduction of DENV-2 despite large numbers of infected residents (13 ), presumably due to cross-protection afforded by prior infection with DENV-1 (14 ).
Moreover, large numbers of infected computers could significantly slow Internet traffic.
Dr. Cohen said New York City would continue efforts to combat the virus by spraying pesticides in areas where large numbers of infected mosquitoes have been trapped.
Dr. Pecoul pointed out that large numbers of infected Africans live in urban areas where, "with a quite simple clinic, you can deal with anti retrovirals".
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