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Due to the large number of concentrations and time steps assessed, treatments and time steps, the p values obtained from the post hoc tests were adjusted to q values to reduce the probability of type I errors of p values using the false discovery rate-correction of Benjamini & Hochberg through the package Q-VALUE in R (R Development Core Team, 2009).
The results show that the Gradient Maker (GM) bioreactor is a more sensitive method for detection of cell toxicity, and compared with testing of drug toxicity using microwells with individual cell cultures, allows one shot testing with a single cell culture exposed to a large number of concentrations.
For assays with very high throughput, an alternative approach would be to simply screen a large number of concentrations over the entire range of compound solubility.
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Populated by a large number of concentration camp survivors, the idea that black-shirted would-be Nazis sporting swastikas would be marching in their streets, past their homes, was a reprise too much to bear.
In the present study, a large number of concentration-time data was used for the population pharmacokinetic analysis.
The comparison between modelled (Fig. 9 (c)) and observed (Fig. 9 (d)) hourly NO X and O3 concentrations shows the model predicts a large number of O3 concentrations in the 0 150 ppb NO X range and 10 30 ppb O3 range, with the equivalent zone of observed concentrations having smaller numbers of hourly values.
Thus, although a large number of metabolite concentrations in metabolic pathways can be simultaneously measured, the metabolic behaviors assumed from measured metabolite concentrations may sometimes not be entirely reliable.
Although micro-invasive, this technique allowed for measurements on many objects and produced a large number of element-concentration data.
We measured a large number of fatty acid concentrations in plasma samples only once during pregnancy.
First, the predominance of grey indicates that many GMRs could not be calculated because of the large number of non-detectable concentrations.
The results can be compared to those found on cells in culture where it was easy to test a large number of different BLM concentrations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com