Additionally, NPs that are internalized early have more time to be transported to larger intracellular vesicles, thus forming large NPCs.
The broadening is also contributed by the complex spectral characteristics of individual large NPCs, as will be discussed next.
We attribute this broadening to the spectral properties of the larger NPCs seen in TEM at t = 24 h (Additional file 1: Figure S3), as large NPCs exhibit more complex spectral properties than monomers and dimers due to the excitation of higher-order modes [55].
The larger 3-, 7-, and 12-NP clusters exhibit various degrees of strong electric fields around/within the NPCs at wavelengths longer than 700 nm (third, fourth, and fifth row of Figure 8), illustrating how large NPCs exhibit more complex spectral properties than monomers and dimers.
The simultaneous presence of newly endocytosed NPs of modest NPC sizes and larger NPCs accumulated from an earlier time creates a range of NPCs confirmed by cellular TEM images (Additional file 1: Figure S3).
Inter-particle coupling, which contributes to the overall optical response of a NPC, can be wavelength-dependent; for larger NPCs, this coupling can be manifested at a broad range of wavelengths red-shifted from the plasmonic resonance of individual AuNPs.
Since then, several large-scale NPC screenings have been carried out in Guangxi, Guangdong and other places, and the screening results show that the early diagnosis rates of NPC in the screened population were all more than 80%[35]], [38], [43]– [43].
Therefore, we reviewed magnetic resonance imaging (MRI) scans of a large sample of NPC patients and documented the patterns of locoregional extension of NPC, aiming to improve CTV delineation.
A large number of NPC gene expression profiles have emerged in public databases.
Thus, the aim of the present study was to determine the prognostic value of MRI-detected CN invasion in a large cohort of NPC patients treated with IMRT.
