Large modifications to the plan were devised by Lieutenant Colonel Oliver North of the National Security Council in late 1985, in which a portion of the proceeds from the weapon sales was diverted to fund anti-Sandinista and anti-communist rebels, or Contras, in Nicaragua.
To comply with the standards recommended by SEEK, users do not need to make large modifications to their current working practices and they do not need to use new applications.
The second protocol tested was based on that of Silberberg et al. [22] and entailed substantially larger modifications to the ACSF than ACSF1.
The use of bioreactors could enhance the decellularization procedure of tissues/organs, but a careful selection of the processing parameters is needed in order to prevent large modifications compared to the native condition.
Therefore on average peptides carrying large modifications might tend to attain lower scores compared to peptides of similar mass but different composition and length that carry small or no modifications at all.
The notion of hypersensitivity is illustrated: a weak geometrical modification, a defect in connexion angle, can under certain conditions lead to large modifications of the vibrational behaviour.
Overexpression of LARGE has been shown to lead to LARGE modification of non-native acceptors, including N-glycans and O-GalNAc glycans, and, potentially as a consequence, to partially rescue functional glycosylation in cells derived from patients deficient in other O-mannosylation pathway activities.
The methods in [7, 8, 9, 10, 11, 12, 13, 14] need large modifications of the radomes or antennas and lead to high cost.
A final notable feature is an accessible surface depression on the opposite side of the binding site, and in line with the propyl group, which could allow larger or planar modifications to interact favorably with Leu28.
Adaptations to a new environment, such as a polluted one, often involve large modifications of the existing phenotypes.
Adaptation to a new environment, such as a polluted one, often involves large modifications of the previous phenotype(s) and changes in gene expression and regulation during critical developmental stages may explain these phenotypic changes.
