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The other consists of the changes brought about by mutations, spontaneous alterations of genes that result in large modifications of the organism and give rise to new species: "The new species thus originates suddenly, it is produced by the existing one without any visible preparation and without transition".
Both multiple mutants display large modifications of stability and activity arising from synergic effects in comparison with single mutations.
Despite large modifications in the membrane composition, the local environment of core complexes remained unaltered, whereas specialized paracrystalline light-harvesting antenna domains grew under low-light conditions.
The methods in [7, 8, 9, 10, 11, 12, 13, 14] need large modifications of the radomes or antennas and lead to high cost.
The notion of hypersensitivity is illustrated: a weak geometrical modification, a defect in connexion angle, can under certain conditions lead to large modifications of the vibrational behaviour.
The use of bioreactors could enhance the decellularization procedure of tissues/organs, but a careful selection of the processing parameters is needed in order to prevent large modifications compared to the native condition.
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If any of the proteins in question would be involved in the post LARGE modification, mutations should not result in loss of ligand binding as the basic ligand binding LARGE glycan scaffold would still be preserved and present.
Compared with popular reanalysis methods, the proposed method can achieve an accurate response for large modification with lower computation cost.
We confirmed that the use of "MTF" caused not only the right direction of the modification by embedding but also too large modification by embedding.
Subsonic shell waves are demonstrated to interact strongly with supersonic shell waves to cause a large modification in the radiated intensity distributions near the shell surface.
The results show that the automated procedure can accurately produce pulse responses corresponding to the mode excitations and the flutter characteristics of AGARD 445.6 wing in a very large modification range.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com