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Given these large methodological differences between the studies, different findings are simply to be expected and do not necessarily illustrate that findings are contradictory.
Although divergent results, there are large methodological differences between the two studies: in the ARIC study, all patients with prevalent coronary disease were excluded from analysis and, consequently, the patients were free of prevalent CVD at baseline.
However, large methodological differences may also be a factor here.
However, large methodological differences between studies make it difficult to integrate findings and draw solid conclusions on the role of cG × E in externalizing behavior.
However, our review also makes clear that even though we specified our search terms by means of a specific environmental factor and outcome most studies have large methodological differences, which makes it difficult to make cross-study comparisons of findings.
However, these probes may target genes without an exact counterpart in the public domain given large methodological differences that exist for defining a gene between the Celera and the public domain approaches.
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7 8 Combining data from various sources to estimate cost-effectiveness over extended time horizons, modelling studies inevitably require a large number of assumptions, 26 and comparisons to our trial-based results are hampered by the great methodological differences.
There are still large methodological and technical differences between the LULUCF assessments provided by Parties.
If there are large clinical or methodological differences between the trials, an appropriate judgment may be to not perform a meta-analysis at all.
Some of this large difference could be explained by the methodological differences used by the different studies.
In the present study, methodological differences between two large centres in Germany (A = Ludwig-Maximilians-University Munich, Germany; B = Forschungszentrum Jülich, Germany) with a high number of 18F-FET PET investigations (> 500/year) and multiple publications in the field were identified.
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