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However, the coating thickness showed a large main effect but an insignificant interaction effect, so it was kept constant.
In general, the two-stage association study had sufficiently high power to detect SNP loci with a large main effect (e.g., genotype relative risk >2).
Importantly, genotype also has a large main effect for these normalized traits.
However, when there were less than 20 variants in the bin, a single variant with a large main effect was easily detected.
We expect causative rare variants to be highly penetrant, but clearly the power of BioBin to detect a signal with a large main effect is greatly affected by the number of other variants in the bin.
Although we found a large main effect for glycemic control at the third clinic visit, BGM frequency was high throughout the 28 days before the clinic visit for children with low A1Cs and increased slightly for those with higher A1Cs.
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These explanatory variables tended to result in large main effects and large interactions.
Regardless of the experimental design, significant and, in some cases, large main effects of 'laboratory' and 'strain' were found for nearly all variables (Table 4).
This assumes that reasonably large main effects are first detected, since mediation effects are partitions of main effects.
Thus, non-linear interactions without large main effects would be missed, i.e. complex signaling regulatory networks [ 8].
One possible explanation of this effect is that previous studies were focused on identifying genes with large main effects associated with clinical outcomes.
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