Exact(5)
5C approach combines 3C and hybrid capture, so it can identify many chromosome interactions between two large loci (many to many).
We analyzed the DNA sequence of several large loci in Salmo salar and other species for the presence of DNA transposon families.
Specifically, large loci have, on average, more mutations than the small ones (three mutations in a (X 3 locus vs. seven mutations in a (X 64 locus).
In addition to small loci (<10 kb) responsible for encoding adhesins and toxins, we compared large loci (>10 kb) containing contiguous genes with highly coordinated functions.
RAYSI (CL30) was localized in four loci on each arm of the Y1 chromosome and in two large loci at the p arm and two minor loci on the q arm of the Y2 chromosome (fig. 4 K).
Similar(55)
Of the two novel genes, KRT31 lies within a large locus encoding multiple keratin genes, in which we also observe associations with blonde hair.
These observations, together with the high spontaneous mutation rate of NF1 (which is consistent with a large locus), suggest that NF1LT represents the elusive NF1 gene.
However, visualizing large locus ranges can cause some display delays due to accessing of large amounts of genomic data.
In "absolute" and "discriminatory" modes we rely on this property to calculate average enrichment levels within a possibly large locus.
Linkage to the LARGE locus was assessed by genotyping two microsatellite markers flanking the gene (D22S281 and D22S529) and two intragenic markers (D22S1162 and D22S1172).
On the other hand, another large locus, LOS 19 covered by 16 clones (from blr6843 to blr6883 at the coordinate 7,540,433 7,575,109), was not potentially induced by SSE but by genistein (Fig. 1 and Supplementary Table S3).
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