I believe that this paper should be accepted, but there is one somewhat large issue regarding sample size that need be addressed first: Throughout the paper, the sample size for the experiments is low (N of 5 to 6 is not uncommon).
Such rapid processes of adaptation and speciation can be used as models to study and understand larger issues regarding the evolution of neotropical plants.
Deloitte has been caught up in a much larger issue regarding the role of Chinese accounting firms that review the financial statements of Chinese companies whose shares are traded in the United States, and whether those firms can be subjected to scrutiny by American regulators.
Larger issue regarding training in the current context is the reorganization of the national health research system, which is incomplete and created a transitional stage.
However, the use of large amounts of acid introduce issues regarding reactor corrosion and acid recovery and requires the treatment of the acid residue, producing a lot of wastes [ 6].
We discuss its interplay with modern data-mining tools (such as Local Feature Analysis and Diffusion Maps) through illustrative examples, and comment on important open issues regarding applications to large systems arising in molecular/atomistic simulations.
In addition, upscaling issues regarding validation and large-scale applications of the RRM are also discussed.
However, a large clinical trial is required to address outstanding issues regarding safety and efficacy in this vulnerable population.
Moreover, issues regarding random access due to the large number of devices using mobile networks are addressed, e.g., in [19] and [21].
As with other large carnivores in the province, the ecological and ethical issues regarding the trophy hunting of cougars must also be addressed.
The Parkinson's disease study reported here can illustrate several issues regarding the search for epistatic effects in large datasets.
