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and used in large intervention trials in children [ 56].
These studies have included large intervention trials [ 27], screening studies [ 28], and other evaluations.
Large intervention trials with acarbose in (pre diabetes provide the strongest evidence.
Large intervention trials with acarbose in (pre diabetes do provide the strongest evidence.
There are few large intervention trials of multiple micronutrient supplementation in non-pregnant women of reproductive age and none have been conducted in Africa.
However, two large intervention trials (HERS and WHI) found no benefit of oestrogen progestin treatment on the risk of cardiovascular events (Hulley et al, 1998; Manson et al, 2003).
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This is the first large intervention trial in The Netherlands to study the effect of telephone counselling by pharmacists on adherence.
Results of a large intervention trial to promote breastfeeding have challenged the evidence that breastfeeding prevents child obesity [ 37].
Various explanations have been suggested: protein deficiency [ 7], hormonal imbalance [ 8], aflatoxin poisoning [ 9], and oxidative stress [ 10], but none have been verified, and a large intervention trial failed to prevent oedematous malnutrition with antioxidant supplements [ 11].
It is assumed that pharmaceuticals such as statins and ACE inhibitors/angiotensin receptor blockers have equivalent benefits in this younger age group because larger intervention trials have not systematically included such young patients with either type of diabetes.
The results of this study may be important for the design of a larger intervention trial with calcium supplementation with fracture as the main outcome.
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