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Hematoxylin and eosin staining indicate a large inflammatory cell infiltration in DEN-treated mice, compared to vehicle control mice.
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The cells lost their normal structure with large amounts of inflammatory cell infiltration ((Fig. 8h) I-8 H IIII and 8(I) I-8(I) III).
In the boundary of the necrotic area, a large amount of inflammatory cell infiltration was found ((Fig. 8j) I-8(J) III).
There was a large amount of inflammatory cell infiltration in the alveolar walls and spaces.
There were a large number of inflammatory cell infiltration and accumulation in the perivascular area.
In 4-day and 7-day groups, the airway epithelial cells underwent obvious necrosis with a large number of inflammatory cell infiltrations, alveolar septa were significantly widened with hyperemia, and perivascular spaces were also filled with inflammatory cells).
In the process of collagenase digestion salivary cells, which are larger than inflammatory cells, may become separated from inflammatory cells as they were washed and centrifuged several times.
3 = severe - Multiple large foci of mononuclear inflammatory cell infiltration in the inter-bundle connective tissue extending into the intra-bundle connective tissue with expansion of the inter-bundle and intra-bundle space.
Rather than being considered part of the neoplastic cell population, macrophages are generally considered part of the tumor stroma as macrophages form a large portion of the inflammatory cell infiltrate in most cancer types [ 33, 34].
In this regard, in an experimental animal model study in mice, vacuolar form of the parasite was reported to cause invasion to the lamina propria, submucosal and muscular layers of the large intestine leading mixed inflammatory cell infiltration and active colitis in infected mice [ 16].
To characterize virus induced inflammation, spinal cords from 7 day p.i. mice were stained with H&E as described previously [ 21, 32] and scored using an inflammation scale: 0 - no inflammation, 0.5 - few inflammatory cells, 1 - inflammatory cells localized near white matter, 1.5 - small patches of inflammatory cells, 2 - large inflammatory plaques, 3 - diffuse inflammation.
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