Sentence examples for large induces from inspiring English sources
However the detailed mechanism by which LARGE induces the functional glycans remains to be elucidated.
The results suggested that stable overexpression of Large induces the functional O-glycans on α-DG to mediate laminin binding in a DPM2/O-mannosylation dependent manner.
This also explains that Large induces the functional glycosylation on N-glycans effectively in galactosylation deficient cells (Lec8) since the GlcNAc terminals are enriched on the N-glycans in galactosylation defective condition.
Introducing the wild-type DPM2 cDNA, the deficient gene in the Lec15.2 cells, fully restored the Large-induced functional glycosylation, suggesting that Large induces the functional glycans in a DPM2/O-mannosylation dependent manner.
With the O-mannosylation null deficient Lec15.2 cells, we demonstrated that stable overexpression of Large induces the functional glycans in a dolichol phosphate-mannose biosynthesis regulatory protein 2 (DPM2)/O-mannosylation dependent manner, thus confirming for the first time that Large is involved in modification of O-mannosyl glycans on α-DG.
Agonists, usually small, induce closure of the binding pocket, leading to opening of the channel pore, whereas antagonists, usually large, induce opening of the binding pocket, thereby stabilizing the closed pore.
These results are consistent with previous observation using transient expression methodology (Fig. 1, 2), suggested that stable overexpression of Large induced the functional glycans independent to Gal, sialic acids, and complex N-linked glycans.
On the other hand, larger induces larger scheduling delay, increasing in this way the value of, that drives lower throughput values.
Second, side chains tend to have larger induced conformational changes when a peptide binds to its protein partner.
We also notice relatively larger induced fields at night, which is expected since the mantle and subsurface stay conducting at night, unlike the E-region of the ionosphere.
Why then, do we not simply see the same effects, only larger, induced by METH vs. DAT blockers?
