Sentence examples for large functional consequences from inspiring English sources

This can lead to large functional consequences on soil structure and thus on air and water fluxes in the soil.

A shift in DNA methylation of 5 10 % indicates that ~5 10%% of DNA molecules in the population assessed become fully methylated (or unmethylated) at that locus, with potentially large functional consequences in that specific cellular sub-population.

Interestingly, despite the huge difference in the expression profiles, these two actin genes only differ by four amino acids, indicating that small mutations between these two genes may have large functional consequences.

Intron retention, or the maintenance of an intron in a mature mRNA transcript, is a less common type of alternative splicing [ 12] and can have large functional consequence by introducing premature mutations to the mature transcript.

Does a 3 times larger dendritic tree have functional consequences for the output of neurons, that is, action potential firing and encoding properties of neurons?

Our results demonstrate that integrated analysis and visualization of multidimensional and heterogeneous data by Anduril enables drawing conclusions on functional consequences of large-scale molecular data.

A central challenge in this framework is thus to link the cellular level analysis of phenotypic effects on microcircuit architecture to the functional consequences for brain function on a larger scale.

The functional consequences of a large number of ATP1A2 mutations causing either FHM or SHM have been investigated in vitro.

The functional consequences of the large TIAM1 isoforms have not been distinguished, but caspase cleavage abolishes TIAM1 activity (14).

Yet, functional consequences of a large number of aberrations are still unclear, and databases containing frequencies of non-pathogenic imbalances (copy number variations = CNVs) in a general population remain to be completed.

Our previous study of the functional consequences of a large set of BRCA1 BRCT variants revealed an intriguing subset of the variants that were stably folded but nevertheless exhibited significantly reduced function in both peptide binding and transcriptional assays, likely through a direct effect on the phosphopeptide binding surface.