Sentence examples for large functional changes from inspiring English sources

The importance of KLF function is underscored by relatively small changes in KLF expression having large functional changes.

Ascending aortic stenosis [28], [29] and heterotopic heart transplantation induce large functional changes in hemodynamic load without major neurohumoral activation.

Likewise, it is reasonable to assume that the large functional changes required as a molecular complex evolves to recognize a non-L1 signal might lead to compensatory changes within Xist RNA, even if the two nucleic acids do not interact directly.

Analysis of the these cases, revealed that the majority of them (77%) contained the nonsense SNP in the final 10% of the corresponding coding sequence, near the 3' end of the other allele (see Table S3), and therefore may not be associated with large functional changes.

If regression to the mean was operating, a large functional change at one visit would be mitigated by a small change at a succeeding visit, all of which would have been included in our analysis.

Higher ω value suggests a relaxed selective constraint on protein coding sequence evolution and that SNPs in genes with weaker selective constraints have larger functional changes.

Earlier studies have shown that estrogen deficiency may induce functional changes in large arteries, but structural changes are more likely to be seen in long-term effects [ 10- 15].

Systems Toxicology is the integration of classical toxicology with quantitative analysis of large networks of molecular and functional changes occurring across multiple levels of biological organization.

At least some of these putative rate shift residues are likely to have contributed to functional changes among the different large subunit groups.

Variants with the DAF less than 1% have the biggest functional changes, whereas variants with DAF larger than 99% have the smallest functional consequences.

Structural and functional changes in small fibers precede large-fiber pathological changes and have been implicated in foot ulceration and delayed wound healing (1– 3).