In our model, hundreds of motif-binding domains in higher eukaryotic proteins connect simple motif specificities with useful functions to create a large functional motif space.
For instance, a "bit" of change in p53 functionality may cause severe phenotypes, whereas a "large" functional effect on other proteins may have little biological impact.
Thus, under the model of 'collateral' expansion, replication of homology units 7 10 and the consequent expansion of subgroups TRAV22, 23, 25 and 26 may have largely been due to evolutionary selection for a large functional TRDV1 repertoire.
In addition, many functions show a broad distribution across the day, often reflecting large functional classes with many genes such as hydrolase activity and signal transduction.
The importance of KLF function is underscored by relatively small changes in KLF expression having large functional changes.
When I arrive, a few minutes late, having accepted the taxi driver's suggestion that we take the scenic route, she is waiting outside her large, functional house, which she has called Widdecombe's Rest.
And so, at our friend's suggestion, we found ourselves in a two-room cottage with a small porch, a tiny blue cotton couch, an old-school television set and a large functional bathroom at Kibbutz Haon, steps from the Sea of Galilee.
After dumping our stuff in our large, functional room, the Sewing Room -- with a queen bed, a slightly updated bathroom and a wall of chalk boards, we practically ran to the Cypress Room, the cigar bar down the hall, and chugged a $3 beer.
The system was launched in 2006 with the "highest standards of security" yet it clearly conforms to Cambridge professor Ross Anderson's rule that a large, functional database can never be entirely secure (while a completely secure database can never be functional).
Such lesions can be considered a morphological toxic response; unless the silica exposure is prolonged, there will be little respiratory impairment because the lungs and certain other organs have a large functional reserve.
This is of particular importance for sessile organisms with large functional surfaces: plants.
