The results indicated that a large fraction of the changes could be accounted for by a nearly linear component in time, which intuitively corresponds simply to some words becoming more frequent and some becoming less frequent.
In both cases the overall slope and large fraction of adaptive changes would be expected to cause directional selection away from the native state.
These two approaches sometimes result in different conclusions; population-based methods can yield an extremely large fraction of adaptive changes (Fay et al. 2001), especially in Drosophila (Sawyer et al. 2003, 2007), while phylogenetic methods often result in more modest estimates of p+ (Nielsen and Yang 2003; Rodrigue et al. 2010).
According to the IPCC, a large fraction of climate change is thus "irreversible on a human time-scale", except if man-made CO2 emissions are sucked out of the atmosphere over a long period.
Examining these persons on a bicycle ergometer, at low energy expenditure a large fraction of the change in nonresting energy expenditure was accounted for by an increase in the mechanical efficiency of exercising skeletal muscle (25).
Notably, a large fraction of the observed changes resulted in previously unannotated gene models.
Secondly, GGEA yields result sets where a large fraction of relevant expression changes can be explained by nearby regulators, such as transcription factors, again improving on set-based methods.
While elutriated and arrested cells have similar patterns of DNA content and cyclin expression, a large fraction of the proteome changes detected in arrested cells are found to reflect arrest-specific responses (i.e., starvation, DNA damage, CDK1 inhibition), rather than physiological cell cycle regulation.
At high vacancy concentration a large fraction of iron atoms change position and are populated in the Co sublattice.
A large fraction of anthropogenic climate change resulting from CO2 emissions is irreversible on a multi-century to millennial time scale, except in the case of a large net removal of CO2 from the atmosphere over a sustained period.
