We observed a number of previously underestimated problems with extraction of histology-based information, in particular, related to the large extent of microscopically apparent tissue shrinkage, which can be countered by addition of live-tissue MRI prior to the implementation of this pipeline.
The model is motivated by the structure of smooth muscle tissues that exhibit perfect elastic (or visco-elastic) behavior in a large extent of deformations.
This combination of properties results in that, at late times, a relatively large amount of radioligand is still in blood, and as the signal from tissue has washed out, the signal measured in the whole ROI consists to a large extent of the signal from blood vessels, and hence, the importance of estimating a correct fraction of vascular signal is emphasized.
The positive findings have been obtained in Rome by using to a large extent cryopreserved tissue fixed with formaldehyde (either prior or after freezing and cutting) but also a smaller number of paraffin samples obtained from Vienna and Amsterdam.
These results suggest that previously reported apparent ongoing injury progression is likely to be due, to a large extent, to clearance of tissue damaged by the primary impact rather than continuing cell death.
Smaller oil droplets with larger variance leads to faster and larger extent of degradation.
Analysis of multiple cell lines has revealed that TADs are to a large extent tissue invariant [ 68, 69], although more detailed and higher-resolution studies are needed.
In the course of our study, we found that the compound accumulated to a large extent in tumour tissues.
Doctors informed him of the extent of tissue damage, causing Liddell anxiety about his future.
The tissue sections were assessed for the extent of tissue digestion (Watters et al, 2000).
