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We cannot exclude the possibility that to a larger extent, several long-range HGLBs were further fragmented by synteny blocks by large evolutionary events, and it is conceivable that chromosomal regions might contain specific "anchor points", which have combined features of long-range chromatin modeling with cis-regulatory and/or other functions.
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The detection of authentic orthologs is frequently impaired by genome rearrangements and other large-scale evolutionary events like WGD.
Reconstructions based on cross-species chromosome painting data provide the most basic ancestral plan, only permitting the arrangement of relatively large-scale evolutionary events to be traced.
The stable model is well suited to a stochastic process with a volatile rate of change in which biological characters undergo a mixture of neutral drift and occasional evolutionary events of large magnitude.
Importantly, our results imply that pathogens may be advantageous to the subsistence and prosperity of hosts through effective HGT events at a large evolutionary scale.
Finally, anomalous pairwise distances directly locate likely horizontal gene transfers and other discontinuous evolutionary events (such as large insertions or deletions, loss of a domain, hidden paralogy, or rapid evolution due to change of function), and indeed our method rediscovers a number of previously proposed horizontal transfers.
Such evolutionary events accompanied with a large structural change in the hatching enzyme genes likely contributed to the diversification of the hatching enzyme genes.
Genome relatedness/evolutionary distance was found to have a large effect on the apparent frequency of evolutionary events affecting TCS genes, but not on the relative dominance of different types of mutations.
They also suggest that evolutionary events restricting the subsequent richness of large clades are common.
Additionally, species with broad geographic distributions with respect to their dispersal potential and species with large population sizes are more likely to show past evolutionary events (e.g. [ 17]).
Further PaLoc losses and exchanges were less clearly discernable among the large number of genomes studied due to the impact of subsequent evolutionary events such as SNP accumulation and shorter recombinations.
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