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At the time, Kingsley's work was the first to show that a single gene could be responsible for a large evolutionary change, such as the loss of an entire set of fins, in natural populations.
We have previously observed a large evolutionary change from hydrophobic amino acids to threonine in the primate lineage (Kitazoe et al. 2008).
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Large evolutionary changes in allometry can be produced by small and simple changes in growth kinetics, and we show how understanding the development of traits can greatly simplify the interpretation of how they evolved.
Even small effects on fitness, however, can result in large evolutionary changes given the cumulative effect of selection over multiple generations.
Indeed, we already noted that while the large evolutionary changes in isochore patterns occurring between mammals/birds and amphibians/fishes mainly depend upon body temperature, definitely other factors play a role as well in the case of fishes.
As fishing in the feeding grounds causes the largest evolutionary change, a spawning-ground reserve can do little to curb these effects.
Our model predicted that the PMRN midpoint (and specifically the PMRN intercept) underwent the largest evolutionary change among all four modeled life-history traits (see also Dunlop et al. 2009b), suggesting that the inclusion of genetic covariances may not have had a large effect on model predictions with regard to this central finding.
Any genome wide screen for large-scale evolutionary change will enrich for false positives.
Can you flesh out how this kind of variation and genetic transfer can occur in populations and thus achieve large-scale evolutionary change?
The neomuran revolution was the largest quantum evolutionary change in cotranslational secretion in the history of life and unsurprisingly therefore caused dramatically rapid and unprecedented changes in the translation apparatus itself, i.e. in ribosomal RNA and proteins [ 1, 5, 29].
The large observed evolutionary changes predict that the A allele would be decreasing in frequency.
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