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Therefore, for our study the authors could only provide the very coarse "small" or "large" estimates of population size.
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Rather, the highly structured P. falciparum population appears to be the result of a population bottleneck, while the much less structured P. vivax population is likely to be derived from an ancient pool of diversity, as reflected in a larger estimate of effective population size for this species.
Also, slightly larger estimates of the parameters relating population size to the population genetic variables analyzed were obtained in this subsample compared to the analyses including the entire data set.
In large populations, estimates of effective population size should be treated with caution, as the genetic-drift signal becomes small, and this may lead to low estimation precision (Hare et al. 2011).
This is known as the curse of dimensionality [ 24], and results in unstable estimates of population parameters from large-sample based methods.
Estimates of population risks.
Eliminating all migration between Asia and the New World (m = 0) results in the largest estimate of Ne for the Amerind founding population of ≈1,200 individuals.
In accordance with this second hypothesis, the roe deer specialist (cluster 2) had the largest estimated effective population size of the three strains.
Chiang II and Silcocks methods produced almost identical life expectancy estimates across a large range of population sizes but calculation failures and excessively large SEs limited their use in small populations.
The bottleneck signal was stronger for P. b. temminckii as a likely consequence of its larger estimated ancestral population size.
To obtain larger units of population for more stable estimates of incidence, small zip codes were combined with the next smallest neighboring zip codes until the aggregated zip code area (AZCA) reached the size of >600 residents or more.
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