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The form of the models used for global burden assessment was motivated largely by the concern that linear extrapolation using these coefficients would produce unrealistically large estimates of RR compared with other known PM2.5-related mortality risks such as active smoking (AS) and exposure to secondhand tobacco smoke (SHS) (Cohen et al. 2004; Ostro 2004).
It is ironic to consider such large estimates of the negative impact on Canadian exports of the post-9/11 border tightening at the same time as opposition to NAFTA is being expressed in the United States.
Where environmental perturbations are large, estimates of theta are likely to be reliable even when measurement errors are also large.
Refitting of a missing covariance matrix via the parametric bootstrapping generated unrealistic large estimates of relative errors in Quercus laeta and Quercus spp. Numerical instability of the covariance matrix, small sample sizes, and random multiplicative residuals with a large variance is a recipe for poor results.
Therefore, for our study the authors could only provide the very coarse "small" or "large" estimates of population size.
An illustration of this may be found both in the progressively low sample sizes for Siskiwit during each developmental time point, and in the large estimates of standard errors in the later time points.
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Finally, we revisit the large estimate of Ne obtained by Rouzine and Coffin [15] by incorporating multiple infections of cells and recombination in their two-locus/two-allele model.
If no corrections are made, then the software will report a very large estimate of β and an even larger standard error.
In particular, the small number of never smoker libraries results in a large estimate of the "preferentially" expressed never smoker tags.
Given the large estimate of TMRCA, our study suggests that the Mundari populations are one of the earliest settlers in the Indian Subcontinent.
The biggest factor for such genes will be a very large estimate of the amount of codon evolution among those lineages.
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