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However, this relies upon having a large enough study population to provide reliable estimates of reclassification in each age-sex stratum.
This inability to validate disease biomarkers has been attributed to the lack of large enough study cohorts as well as standardization in sample collection and storage.
Regarding the non-VC maneuver however, no cutoff value has been proposed by a large enough study, thus additional studies are needed for the establishment of such cutoffs and further standardization of the technique.
If the population is large enough, study hypotheses that involve infrequent outcomes or exposures can be addressed as well as hypotheses that involve small effects of common exposures and outcomes[ 4].
37 The rule estimates that in a large enough study (ie, >30 participants), if no event occurs, there is a 95% confidence that the event would not actually occur more often than once in n/3 people, where n is the sample size.
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Those who voted yes tended to think it would be impossible to do large enough studies to rule out the cancer risk before approval.
Areas of future research would include large enough studies to assess the accuracy of scan interpretation in a clinical environment, which will require a substantial number of positive scans.
We believe that our study population was large enough to study this issue.
CAIX and Glut-1 showed the expected positive correlation with HIF-1α (p = 0.006, p = 0.017, respectively), especially with perinecrotic HIF-1α [ 31], indicating that the study group is large enough to study the hypoxic response.
As far as we know, no studies have been large enough to study severe acute maternal morbidity among planned home births.
Second, even though this trial is by far is the largest of its kind, the study sample was not large enough to study participant subgroups (i.e., sex and race or to assess sex-treatment or race-treatment interactions).
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CEO of Professional Science Editing for Scientists @ prosciediting.com