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Consequently, a large effort has been devoted to design specific molecules that interfere with these signaling cascades involved in tumorigenesis.
Therefore, a large effort has been devoted to identify structural types, details and materials commonly adopted during the reference period.
Besides, these diagrams do not consider spatial constraints on site and large effort has to be put into the diagrams to incorporate space as a resource.
Although large effort has been focused on the investigation of their potential application, characterization of ILs properties and structure property relationships of ILs are poorly understood.
Moreover, a large effort has been put to screen sorghum (C4) mutants with increased vein spacing and rice (C3) mutants with reduced vein spacing so that the genes controlling vein spacing trait can be identified (Rizal et al. 2012).
To date, a large effort has been devoted to the development of the MACSIS code for metallic fuel rod design and the evaluation of operational limits under irradiation conditions.
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The largest effort has been through the NIEHS/EPA Centers for Children's Environmental Health and Disease Prevention Research (http://www.niehs.nih.gov/translat/children/children.htm ), where two centers focus on autism.
Over the years, numerous large efforts have promoted more screening.
Large efforts have been devoted to the synthesis methods and the morphological regulation of silver nanoparticles.
Large efforts have focused on engineering new properties into fluorescent proteins via rational design and directed evolution.
Due to the time-consuming nature of executing subjective experiments, large efforts have been made to develop objective quality metrics, alternatively called as objective quality methods.
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