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On the other hand, if there are loci of large effect that exceed generally accepted genome-wide significance thresholds, these are likely to be found in genic regions.
Loci with small birth date ASEs are either of small effect on the selection objective or represent genes of large effect that have undesirable pleiotropic effects (or closely linked loci with antagonistic phase relationships).
Following adjustment for baseline fatigue, fatigue severity was lower in MBCT participants relative to controls, which corresponded to a large effect that was maintained at the 6-month follow-up.
Besides the small genome size that may cause overestimation of the accuracy of GEBV in our simulation, additive effects were sampled from a gamma distribution, which results in some QTL with a large effect that may account for a substantial part of the additive variance.
The review cited the analyses of Eyre-Walker, who says that, for complex conditions evolving under selection, "most of the variance in fitness is contributed by mutations of large effect that are very rare in the population" 30 (p. 1755), a conclusion similarly made by others.
Research has shown the large effect that occupants have on buildings' performance.
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Mr Clark suggests that family history has large effects that persist for much greater spans of time.
Publication year and sample size were positively correlated (ρ = .64), which suggests that certain of the large effects that have been found in the past may have been due to sampling error.
MSP is known to have higher power to detect large effects that may have high variance (i.e., it is more dependent on effect size), while GSMA has higher power to detect effects with small variance (i.e., is more dependent on consistency of results) across independent studies [43].
For complex traits though, linkage is limited to detecting large effects that may reflect a summary of effects over vast genetic distances.
However, in contrast to the medium to large effects that were significant with the current sample size, these effects would be rather small and consequently less meaningful.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com