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The tumors of the other two cases had large edema around the primary tumor.
CO, cardiac output; EVLW, extravascular lung water; LE, large edema; LE + PEEP, large edema + positive end-expiratory pressure; MAP, mean arterial pressure; Pplat, plateau pressure; SE, small edema; SE + PEEP, small edema + positive end-expiratory pressure.
Unfortunately, 3 months after cessation of therapy symptomatic progression due to large edema was diagnosed and combination treatment of bevacizumab and irinotecan was initiated.
AFC: alveolar fluid clearance; CO: cardiac output; EVLW: extravascular lung water; LE: large edema; PE: pulmonary edema; PEEP: positive end-expiratory pressure; SE: small edema.
In this critical situation of massive inflammation, hypovolemia, and large edema formation, it remains unclear whether a "crystalloid only" therapy or a combination of crystalloids plus colloids should be used for volume resuscitation.
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Preliminary studies have shown that this dose of carrageenan induces a medium-large edema in comparison with a maximum dose.
In the group with the larger edema, PEEP application induced a CO decrease that was maintained throughout the experiment, although it was more marked at the first determination with PEEP (time 0).
A possible explanation of this finding may be larger edema in the thigh with an intertrochanteric fracture, with pain and reduced knee-extension strength (Foss et al. 2009, Kristensen et al. 2009b).
In the large-edema (LE) group (n = 5), edema was induced by intratracheal instillation of 10 ml/kg of saline solution.
In the large-edema with PEEP (LE + PEEP) group (n = 5), edema was induced by intratracheal instillation of 10 ml/kg saline solution, applying PEEP of 10 cm H2O immediately after the first determination of EVLW (before time 0).
Although the absolute amount of liquid resorbed (in ml) was higher in the large-edema group, the AFC rate (in %) was similar among the groups and independent of the amount of edema.
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