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There is a need to develop synthetic scaffolds to repair large defects in load-bearing bones.
The fatigue life is – besides many other factors – governed by the large defects in the highly stressed area.
The presence of ettringite may play a role in this enhanced microporosity, in the form of large defects in the crystalline ettringite, or voids in the ettringite crystals.
Fresh allografts present the advantage of having mature viable hyaline cartilage, not causing donor morbidity, allowing the restoration of even large defects in a single surgical session.
Removal of damaged physis or bony bar and insertion of spacers produced variable results and for large defects in young children, the treatment is challenging.
Three-dimensional PLGA scaffolds seeded with cultured MSCs were transplanted into large defects in rabbit knees and analyzed histologically at 4 and 12 weeks after the operation.
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The destructive test shows a large defect in area a in this seam section.
Pelvic exenteration results in a large defect in the pelvic floor, increasing the likelihood of internal organs herniating into the infectious wound.
We considered that tumor excision was essential to enable adequate wound treatment; this tumor excision resulted in a large defect in the pelvic floor.
Tumor resection resulted in a large defect in the pelvic floor, increasing the likelihood of internal organs herniating into the infectious wound.
The defects were clearly distinguishable on MRI three and six months postoperative with a persistent large defect in the empty defects and smooth and slightly depressed surface of non-hyaline tissue in the MACI group (Fig. 4).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com