Given the large resource and cost implications of DOT, policy makers might want to reconsider strategies that depend on direct observation.
This may have cost implications for large cohort studies where repeated measurements, more labour intensive instruments, or biomarkers may be needed for a large subsample in order to provide adequate precision to adjusted estimates.
The cost implications of that are very large.
Although using very large dishes may have a few advantages, the cost implications need to be analyzed before implementing such designs.
Therefore, with the exception of drink driving campaigns, recent public health alcohol messages have failed to impact on the behaviour of a large audience, with potentially significant financial and public health cost implications.
Further tracing and advertising work would have had considerable time and cost implications and the funders suggested that further large-scale mailing would not be cost-effective.
Indeed attitudes to participation in large clinical trials may not differ according to ethnicity, but there remain cost implications to the inclusion of non-English speaking/writing individuals in such research [ 27].
We note that cost implications, for dichotomous assessments, are quite important particularly when n is larger than two, which we intend to report on in a future paper.
Typically, a large number of optimization experiments are required to achieve a highly optimized search method, which due to cost implications of conducting LC-MS/MS analyses was not feasible.
There is a large variation in the proportions of patients undergoing rehabilitation, and of those rehabilitated in hospital among those rehabilitated, with considerable cost implications.
Even the measures that are being proposed will have considerable cost implications.
