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Unfortunately, though, there is large concern about the quality of such studies and it is clear that large progress is needed to produce clinically relevant results (Hinestrosa et al, 2007).
One large concern about the use of ZFNs, TALENs and CRISPRs – all of which are designed, after all, to introduce DSBs into genomic DNA – is that they will not only cleave at 'on-target' sites but also at 'off-target' sites.
Similar(57)
It is part of a larger concern about how we are becoming endlessly entangled with technology of every type.
But in a new book, "His Brother's Keeper: Israel and Diaspora Jewry in the 21st Century" (Schocken), he discusses a larger concern, about Jewish continuity worldwide.
Then he wrote, "Seriously, we would very much appreciate your input and expertise!" To some critics, the participation of G.E., one of the biggest corporations in America, in a meeting ostensibly about small-business concerns is one example of a larger concern about the Office of Advocacy.
They are small details, but part of larger concerns about his future.
"I find this ludicrous and a copout for the larger concerns about what has been going on," he wrote.
"You can cast it as symbolic of larger concerns about race, which is still an important subject and which people are still interested in".
But the Bank of Italy's actions underscore larger concerns about the transparency of the Vatican's finances, something that Pope Benedict XVI has promised to fix.
Those results did little to assuage larger concerns about company profits in the midst of a deep recession, but they offered investors some room for hope.
Troubles in the housing market have also generated larger concerns about the economy as a whole and the possibility that the country may enter a recession.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com