Sentence examples for large combination trials from inspiring English sources

Several large combination trials in lung cancers are ongoing.

Several large combination trials are ongoing including the combination of an anti-EGFR and MEDI4736 in advanced NSCLC, its sequential administration after concurrent chemoradiation in stage III or vs placebo after a complete resection.

The COMBO-DN study that has just been completed (81) is the largest combination trial in painful DSPN and assessed whether combining standard doses of duloxetine and pregabalin is superior to increasing each drug to its maximum recommended dose in patients with incomplete pain relief.

Analysis of large combination chemotherapy trials revealed that peritoneal carcinomatosis among patients with metastatic colorectal cancer is associated with a 30%% reduction in overall survival (10.7 vs. 17.6 months).

Including COBRA (Combinatietherapie Bij Reumatoide Artritis) [ 57] and a large US combination trial [ 58], these were among the first to clearly demonstrate that early combination therapy was superior to monotherapy.

Prior to being introduced into large clinical trials, novel combination therapies should be supported by in vitro models, however, healthy skepticism should be maintained since robust preclinical data may not always translate into meaningful clinical benefit, as illustrated by the recent disappointing results of combination trials with an FTI or an mTOR inhibitor.

It is not feasible to carry out a large number of large field trials of different combinations to determine the impact of each factor on different malariological outcomes.

In a single disease, investigators can conduct preliminary comparisons to make estimates regarding which markers represent the best opportunities for future validation and qualification studies in large trials, including combination therapy trials.

Four large randomised trials of paclitaxel in combination with platinum against a platinum-based control treatment have now been published in full, representing around 88% (3588 out of 4057) of patients randomised into the eight known trials of this question.

If the findings of this study suggest improved PFS from mutation-targeted and/or combination treatment, larger randomised trials to confirm the findings will be developed.

This information should guide the choice of comparators, including their dose and combinations, for future large trials.