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While cancer cell line panels such as the NCI60 are prepared from 4 5 cell lines of a given tissue origin, this study use a large collection of cell lines of the same type.
The ATCC and ECACC databases are large collection of cell lines and metadata associated with them.
This Encyclopedia of DNA Elements (ENCODE) data describe areas hypersensitive to DNase as determined by assay in a large collection of cell types.
The large collection of cell lines, drug sensitivity, and genomic datasets have enhanced our understanding of cancer cell genomic heterogeneity and facilitated the discovery of new patient-specific treatments.
Examination of patterns of sensitivity across a large collection of cell lines revealed an opportunity to use cancer cell line profiling data as another unbiased approach to identifying small-molecule mechanisms of action.
Of interest, as shown in Figure 3A, the analysis of this large collection of cell lines showed that Bik is expressed only in the presence of TEF mRNA, except for XG2 cell line, indicating that Bik gene could be transcriptionally activated by TEF in myeloma cells.
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They began with a large collection of cells, introduced random mutations and then exposed the cells to a virus designed to mimic Ebola.
Computational homogenization method gives the effective elastic properties of an infinitely large collection of cells out of a calculation on the representative cell.
The G protein-coupled receptor (GPCR) superfamily constitutes the largest collection of cell surface signaling proteins with approximately 800 members in the human genome.
This is the typical assumption made by partial differential equation (PDE) models of large collections of cells where individual cell shapes do not play a role in the behavior of the tissue.
As no cell-type-specific interactomes are available, we integrated the FANTOM5 project cell-type-specific gene expression data with 32,275 PPIs from the STRING database [ 12] to build the largest collection of cell-type-specific interactomes currently available.
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