In units where policies of conservative transfusion and single donors are applied, it would seem reasonable to discontinue the use of early EPO treatment for very preterm infants for which the administration procedure is painful, the large scale clinical efficacy is modest and the absence of side effects does not appear to be fully established.
In addition, we recently reported that a bolus of RhEPO in patients with an acute myocardial infarction was safe and feasible [ 13], and a larger randomized, clinical efficacy trial is currently ongoing (ClinicalTrials.gov number: NCT00449488).
Ideally, every large clinical trial assessing efficacy and safety of new oncological treatments should include a questionnaire-based QoL assessment, enabling more precise estimation of the associated adverse events.
Large, well‐designed observational or clinical efficacy and safety randomized clinical trials are required to identify the prevalence of premature ejaculation (PE) and its associated risk factors, to characterize the dimensions of PE and the basis for treatment‐seeking behaviour, and to achieve regulatory approval of new drug treatments.
Further large clinical trials evaluating the efficacy of A3309 in patients with CIC and IBS-C are warranted.
This review discusses all large clinical trials exploring the efficacy and safety of DrotAA and proposes recommendations for the use of DrotAA in severe sepsis.
Whereas epidemiological and pathophysiological growing evidence demonstrated a direct link between hyperglycemia and cardiovascular morbidity and mortality in diabetic patients, the results of large clinical trials, investigating the efficacy of improving glycemic control in both type 1 and type 2 diabetes to reduce cardiovascular events, have not been convincing.
However, there is a clear need for large-scale, well-controlled clinical efficacy and safety studies in this field.
A detailed analysis of the large clinical evidence base for ranibizumab efficacy and safety in the treatment of neovascular AMD is discussed, including efficacy measures such as visual acuity (VA) and anatomic outcomes, as well as safety and tolerability data for ranibizumab in neovascular AMD patients.
To date, there have been no randomized controlled trials large enough to determine the clinical efficacy of statins in patients with pneumonia.
