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Large clinical changes were in role physical and bodily pain among participants with low SOC (Table 5).
According to Cohen's criterion (p. 40), an effect size of ≤ 0.20 is considered small, 0.50 moderate, and 0.80 large clinical changes [ 38].
Participants with a high sense of coherence (SOC) showed large clinical changes (0.8) at 12 months compared to baseline in role physical and satisfaction in daily occupations.
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This represents a large clinical change, with an effect size of 0.98.
Despite a large positive clinical change (Effect size 1.2) in role physical for the whole group, it was that domain that differed most from population norms (Z-score -1.0) (Table 3).
However, data available from large clinical trials indicate that changes of amyloid-β signal were not associated with changes of disease clinical severity in patients with AD [ 19, 41] and, to date, should not be used as a surrogate marker for efficacy.
Relative risk of stroke or myocardial infarction in older adults without a history of cardiovascular disease increases by 35% with an increase in cIMT of 1 SD, i.e. a relatively large clinical effect for a small change in cIMT [ 26].
To our knowledge, our study is the first to quantify the effect of symptomatic hypoglycemia on chronic brain structure changes in a large clinical cohort of treated older T2DM patients.
Effect sizes within both groups were large at all time periods, indicating significant clinical changes.
The WPS was responsive to clinical changes, with responders reporting larger improvements at week 12 in WPS scores versus nonresponders.
WPS was also responsive to clinical changes, with responders having significantly larger improvements at Week 12 in WPS scores versus non-responders.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com