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These costs become prohibitive when the structural model undergoes large changes from the baseline design, as within an aircraft design process.
FACETS contains a realistic representation of key infrastructure, while retaining the flexibility to explore deep carbon emission reductions and other large changes from the baseline energy system.
In concreto, "Plastic products", "Printing, plate making and book binding", "Real estate rental services", "Research and development (intra-enterprise)" and "Sewage disposal" are the top five sectors showing large changes from 2000 to 2005.
A few watersheds had large changes from more than one metric (MAF, CT, or LFD), and are thus more vulnerable to climate warming than surrounding watersheds.
The large and mostly unexplained placebo effect that we observed resulted in neither aclidinium/formoterol FDC dose, causing significantly greater SGRQ improvements compared with placebo, despite producing large changes from baseline.
Of note, a positive LR above 10 and negative LR below 0.1 has been noted to generate large changes from pre-test to post-test probability of disease, often resulting in a large change in patient management; whereas positive LRs between 5 and 10 and negative LRs between 0.1 and 0.2 are considered to generate moderate shifts in pre-test to post-test probability of disease [ 65- 68].
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All three models indicate an abrupt large change from the proton flux given by AP8MAX and do not seem suitable to account for the solar cell degradation.
For marijuana without alcohol use, the percentage change was mostly negative, with the largest negative decrease between 17 and 18 (decrease of 1.7%) and another large change from 20 to 21 (decrease of 1.5%).
In particular, one large change from pre to post-test was in the Adaptive mutation misconception, which was the one misconception that did not see a significant improvement in the previous study (see Fig. 6 in Abraham et al. 2009).
Forestry in Galicia has experienced a large change from the middle 1980s as a consequence of an aggressive forest exploitation due to the introduction of fast growing forest species to be used as raw material for production of pulp.
Examining the percentage change from year to year, for alcohol without marijuana use, the percentage change was positive in every year, with the highest change between age 19 and 20 (increase of 7.2%), and another large change from 20 to 21 (increase of 6.7%).
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