In further renditions of the model, it will be important to test the effect of larger capillary networks; the presence of other cells and tissues; and the effect of apoptosis and vessel pruning.
That is, individuals with larger lungs likely also have a larger pulmonary capillary network and, therefore, are able to maintain a reserve to recruit and/or distend the pulmonary capillaries in response to exercise at high altitude in spite of the underlying pulmonary vascular recruitment associated with hypoxic pulmonary vasoconstriction.
As the airspaces grow larger in size, the capillary network expands through both sprouting and intussuscepted growth [17].
Morphological examination of the H&E-stained sections showed a rich capillary network and large sinusoid-like vessels, especially in VEGF tumours.
In wildtype mice, CD31 staining showed the expected pattern of pulmonary vasculature development throughout the lung with normal appearance of large blood vessels and an extensive capillary network surrounding the distal epithelium (Fig. 4A,C,E).
Both tumour models showed large numbers of capillaries, but the capillary network was more distorted and non-continuous in FGF8b tumours.
This tree delivers blood to an extensive and expanding capillary network with a large surface area for exchange and is vital for fetal growth and survival.
Each filament contains a capillary network that provides a large surface area for exchanging oxygen and carbon dioxide.
Microspheres that are 20 40 µm in size are optimal for this purpose because they are small enough to reach the arteriolar network in and around the tumor but too large to freely cross over through the capillary network (usually 8 10 µm in size) into the venular side.
Tissues such as liver and kidney had extensive capillary network, therefore, it might make large quantities of drugs accumulate in liver and kidney.
