Since it contains mainly small globular proteins with one stereotypical large binding site it can be seen as a rather "easy" dataset.
It is now shown that a large binding site for a protein antigen (lysozyme) can also be transplanted from mouse to human heavy chain.
The acrylic acid-rich layer on the latex particles surface offered a large binding site for attachment of DNA capture probes to create a maximal covered surface by the DNA receptive layer.
As for the histone binding protein (which will not be named explicitly for confidentiality reasons), it is involved in DNA replication and has a rather flat and large binding site, with a solvent accessible area of 1868 Å2, compared to the surface of the entire protein, 8306 Å2.
In a previous study, the FTMap solvent mapping program (Brenke et al. 2009) was used to identify two main ligand binding regions within PPARγ's large binding site (Sheu et al. 2005).
The PGP ability to bind a variety of structures was hypothesized to result from the presence of a large binding site with a set of hydrophobic and hydrogen-bonding points, which can anchor substrate molecules in different binding modes.
On the basis of many biochemical data, it is likely that the large binding site within the TMDs includes subsites with overlapping but distinct substrate preferences, and this could result in multiple drug translocation pathways.
To further minimize the possibility that merged targets might create larger binding sites, we reduced the radius of targets to 30 nm while maintaining the minimal distance between the centers of two targets at 80 nm.
