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POCS provides an accurate diagnostic yield regarding intraepithelial neoplasia in the large bile duct.
Invasive IPNB originates in the intrahepatic large bile ducts and shows a pattern of intraductal growth.
Balloon-assisted cholangioscopy (BAC) has mostly been reported in Asian patients with large bile ducts.
Cholangiocarcinomas (CCAs) are diverse epithelial tumors arising from the liver or large bile ducts with features of cholangiocyte differentiation.
This case showed a mass-forming growth pattern, with no discernible papillary histological constructions or cyst-like structures in offshoots of the intrahepatic large bile ducts.
Recently, endoscopic biliary sphincterotomy (EBS) followed by large-diameter balloon dilation has been used for the removal of large bile duct stones.
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Enhancing the resolution with pure shift DOSY experiments[ 22] was unsuccessful due to fast transverse relaxation in the large bile-acid micelles.
They eventually join with other canaliculi, forming progressively larger bile ducts that eventually emerge from the porta hepatis as the hepatic duct.
In fetal livers, LGR5-positive cells were located in the ductal plate and in the epithelium of larger bile ducts.
It is likely that PI and IG type tumors arise from malignant transformation of epithelial cells lining the larger bile ducts, whereas the MF type arises from smaller bile ducts or liver progenitor cells within portal areas [ 36].
Morphologically, they make-up the cuboidal epithelium in the small interlobular bile ducts, but become progressively columnar and mucus-secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.
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