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Patients with symptomatic brain metastases, large ascites, or pleural effusion were not eligible.
Abdominal computed tomography showed large ascites with prominent ovaries bilaterally but no definitive mass or lymphadenopathy.
High serum concentrations of CA-125 before surgery were significantly associated with age (p = 0.046) and large ascites volume (p = 0.004).
The causes of low A2M proven false negatives were patients with large ascites or severe undernutrition with total proteins lower than 50 g/L.
There were eight proven false negatives of FT: 5 due to low A2M (large ascites or severe undernutrition) (additional file 5, Table S12), and three due to high ApoA1 (additional file 5, Table S13).
High TIMP-1 concentration after chemotherapy was associated with decreased overall survival (p = 0.007) and patients with large ascites volume had higher TIMP-1 concentrations at this time point (p = 0.032).
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Suspected risk factors were those mentioned in publications: ethnicity, HIV (including cholestatic anti viral drugs), large ascite and undernutrition [ 3, 4, 8, 22- 24].
An abdominal CT scan and MRI showed large volume ascites, splenomegaly and portal-systemic collaterals.
The presence of large volume ascites causes abdominal discomfort, anorexia, nausea and vomiting, and deterioration in quality of life.
In the 13 patients without HPS the pathologically reduced SaO2 was caused by chronic obstructive lung disease (n = 9), large volume ascites, atrial septum defect, the fall of SaO2 with normal initial value was seen in a patient with large volume ascites and a patient with portopulmonary hypertension, respectively.
Between February 2003 through March 2008, patients with advanced stage IIIC and IV ovarian cancer and large volume ascites (>500 mL) were treated with neoadjuvant chemotherapy as part of a multicenter prospective randomized phase 2 trial [ 23].
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