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Calcium, as a ubiquitous second messenger, governs a large array of cellular processes and is necessary for cell survival.
However, such studies emphasize the organizational relationship between components rather than the components themselves, an important focus in the emerging age of "proteomics" in which, in the post human genome era, the complex, functional interactions of the large array of cellular proteins is being studied (Kumar & Snyder 2002).
Actin is involved in a large array of cellular functions.
This pathway is a major control point for regulating, among other things, short-lived proteins functioning as regulatory factors in a large array of cellular processes like cell-cycle progression [ 35], cell growth, stage-specific gene transcription [ 36], inflammatory response [ 37], and antigen processing [ 32].
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Large arrays of cellular actuators can pose a different problem altogether; signal routing from the main controller becomes unwieldy and fault-prone.
The circadian clock is a key element in homeostatic regulation by controlling a large array of genes implicated in cellular metabolism.
RACK1 is a ubiquitously expressed protein that interacts with a large array of signaling molecules, regulating cellular functions such as adhesion, movement, and division [42].
Indeed, it achieves better structural resolution (quantifies single peptides/sites) and high sensitivity in monitoring a large array of phosphorylations involved in many cellular functions and removes aforementioned ambiguities associated with the analysis based on the isolation of pY-proteins.
These different observations are not in accord with the idea that NCLDV, and especially the giant representatives of the family, have undergone a simplification process by loosing a large array of genes from a complex cellular ancestor [ 8].
Recently it has become apparent that the complex genetic and epigenetic gene regulation in aging is also affected by a large array of microRNA [ 40- 48], that contribute to the cellular signalling [ 49- 58], which in turn regulate several cellular function, such as for example metabolism [ 59- 64], cell division [ 65- 66], or DNA damage [ 67- 70].
Protein association is involved in a large array of biological processes: ligand-receptor interactions associated with cellular response to its environment, trafficking through export and fusion proteins, and antibiotic resistance mechanisms induced by efflux pumps [1] [4].
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