Sentence examples for large annotation from inspiring English sources
In contrast to many published transcriptomic studies [1], [11], we did not focus on a particular gene with a known function or large annotation that can be assumed to have a link with viral infection.
The links were extracted from large annotation sets.
Hocking et al. (2013) observed large annotation error rates for several segmentation algorithms applied to a large database of neuroblastoma tumors.
It can be used with any biomolecular database that stores annotation data to perform the transitive relationship approach on large annotation data sets efficiently and effectively.
In any case, the original data was stored in the database without modifying the data itself (i.e. data was just integrated, standardized and arranged to a MySQL database format), thus users are not forced to store large annotation files anymore.
In the Bioinformatics domain, association rule mining has been previously successfully applied to large annotation sets with the aim to find relationships between gene functions described with Gene Ontology (GO) (Botstein et al., 2000; Kumar et al., 2004; Manda et al., 2012).
Our analysis of the causes of missed genes suggests that larger annotation centers tend to produce annotations with fewer missed genes than smaller centers, and many of the missed genes are short genes <300 bp.
Another downside of using a larger annotation database is calculation of adjusted p values, because the adjustment of the raw p value to allow for multiple testing is mainly determined by the number of genes in the model.
In addition, many large genome annotation centers provide annotation services, such as the Annotation Engine at the J. Craig Venter Institute (JCVI) [8], the Genoscope's annotation service MicroScope [12], and the Microbial Annotation Pipeline of the Integrated Microbial Genomes system [10].
The extent of differences in annotations was particularly large in annotation categories of most interest, namely, putative LoF and nonsynonymous variants.
Despite this large number, annotation was feasible because the frames were only partially annotated (focusing on one or few tracks only), unlike the segmentation ground truth that would have required fully annotated frames.
