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A limitation of this study was the large amount of missing values in both questionnaires.
Variables related to smoking, alcohol consumpion, income or type of household contained relatively large amount of missing values (figure 3).
18 Owing to the large amount of missing values on creatinine level, calculations of eGFR were available only in five visits and could not be a global criteria for defining CKD as the main exposure.
Here, the large amount of missing values in our GBS data motivated us to use MI to account for imputation uncertainty and make sound inferences about marker-trait associations.
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However, GBS as used in this investigation yielded data containing large amounts of missing values.
This method may be used for the analysis of data with large amounts of missing values [ 18, 24 – 28 ].
It was assumed that analyzing data that contained large amounts of missing values would result in findings that could not be generalized and lead to substantial overestimated values.
The retrospective character of the study also constitutes a limitation, mainly attributable to the lack of certain management details (e.g. intervals between treatment changes), more precise information about dietary patterns of patients and the large amount of missing data for HbA1c values at diabetes diagnosis.
The strengths of this study include the large sample size and little amount of missing values only in a comprehensive and standardized data assessment.
While the percentage of cases with missing values was very low for the 4 measures of satisfaction, the omission of the practice demographics questions from the 2002 survey resulted in a large amount of missing data.
The biggest differences were observed with RCT 9, which had a large amount of missing data.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com