Exact(1)
We found a large alignment between CardioNet and both mitochondrial networks with 90.48% and 92.49% of the mitochondrial network reactions are represented in CardioNet.
Similar(59)
The first makes sure that the score of the largest ungapped alignment between two profiles passes a threshold.
(The large-scale alignment between the AluSg consensus and the TSC2 RE1 flanked by genomic sequences, leaves practically no doubt that the Alu repeat was indeed a progenitor of this functional p53 site - the 'divergence' ratio (div) is a mere 10.5% for the 290 bp-long DNA fragments (Additional File 3: Figure S2).
In our view, the challenge of adequately visualizing such very large alignments, or alignments with a large divergence between species lies not in finding a visualization that shows every detail at maximum resolution, but rather in appropriate summarization and a (semi-automatic) focusing on the important events.
With a relatively large region, sequence alignment between any two mammalian species can provide too much aligning sequence, resulting in the over-identification of sequences that are not actually preserved due to selective processes and are thus less likely to be functional [ 12].
These insertions and deletions are in low-homology portions of the domain and form large, gapped regions in the alignment between areas of high homology.
Only the largest alignments are reported.
Finally, we also found a subtle but significant positive correlation between the contact accuracy for identified coevolving residue pairs and the number of sequences in an alignment, suggesting that larger alignments yielded increased accuracy (R = 0.1003, p<0.001; Figure S3D).
The underlying philosophy was that if genome maps were correctly assembled, there should be a large proportion of alignments between genome sequences and maps.
The key component of this tool is a graphic interface with a 2D map that displays large amounts of alignments between metagenomic sequences from one or more samples and a reference genome (Fig. 1).
Hence, larger responses lead to a faster alignment between the clock phase and the LD cycle.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com