When gamma-secretase doesn't work properly, these amyloid-beta peptides can accumulate in the brain and large accumulations of these peptides have been observed in the brains of patients with Alzheimer's disease.
Large accumulations of items do a particular kind of job.
There are large accumulations of geologically young, unconsolidated sediments in numerous intermontane depressions.
Precipitation is abundant, and large accumulations of snow can occur in winter, especially at higher elevations.
This behaviour causes serious problems at water intakes, where ice particles may adhere and then build up large accumulations that act to block the intake.
The company has identified a belt across Europe from the Baltic countries to the Mediterranean that it predicts may hold large accumulations of extractable shale gas.
She is as drawn to systematically organized natural history collections as she is to the anarchy of Mr. Buckminster's junkyard, and especially fascinated by the anomalies and serendipitous patterns that can be found in large accumulations of stuff.
In larger, deeper rivers, frazil produced in upstream reaches may be carried downstream and be transported beneath the fixed ice cover, where it may deposit and form large accumulations that are called hanging dams.
Large accumulations are known to exist in artesian basins and beneath the dipping plains at the foot of mountains; those basins are associated with the extensive oases of Central Asia, Kashgaria, and many other regions.
One of the interesting things about oysters as a species is that whereas clams dig into the mud and mussels live on pilings or outcroppings of rocks, oysters actually attach to each other's shells and naturally grow up into these large accumulations we refer to as oyster reefs or oyster beds.
While small amounts of Sargassum are normally found in the Caribbean from May to September when regional currents and winds transport the floating algae to the islands, such large accumulations across so many regions, he said, has "never happened in living memory".
